6LRL

Human cGAS catalytic domain bound with compound s2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (B, A)	Cyclic GMP-AMP synthase	polymer	366	42759.3	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266)	Homo sapiens (Human)	h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	C, E (B, A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D (B)	3-[[5-(1,2,4-triazol-4-yl)-4H-1,2,4-triazol-3-yl]carbonylamino]benzoic acid	non-polymer		299.2	1	Chemie (ER9)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85518.5
Non-Polymers*	Number of molecules	3
	Total formula weight	430.1
All*	Total formula weight	85948.6

*Water molecules are not included.