6LRE

Human cGAS catalytic domain bound with compound 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cyclic GMP-AMP synthase	polymer	366	42759.3	2	UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266)	Homo sapiens (Human)	h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1
2	C, E (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, F (A, B)	1,3-bis(oxidanylidene)benzo[de]isoquinoline-6,7-dicarboxylic acid	non-polymer		285.2	2	Chemie (EQL)
4	G, H (A, B)	water	water		18.0	33	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	85518.5
Non-Polymers*	Number of molecules	4
	Total formula weight	701.2
All*	Total formula weight	86219.8

*Water molecules are not included.