6LPU

Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with L-2-hydroxyglutarate (L-2-HG)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	D-2-hydroxyglutarate dehydrogenase, mitochondrial	polymer	481	52332.9	2	UniProt (Q8N465) Pfam (PF01565) Pfam (PF02913) In PDB	Homo sapiens (Human)
2	A, B	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	(2S)-2-HYDROXYPENTANEDIOIC ACID	non-polymer		148.1	2	Chemie (S2G)

Sequence modifications

A, B: 51 - 521 (UniProt: Q8N465)

PDB	External Database	Details
Gly 47	-	expression tag
Pro 48	-	expression tag
Gly 49	-	expression tag
Ser 50	-	expression tag
His 522	-	expression tag
His 523	-	expression tag
His 524	-	expression tag
His 525	-	expression tag
His 526	-	expression tag
His 527	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104665.8
Non-Polymers*	Number of molecules	6
	Total formula weight	1998.1
All*	Total formula weight	106663.9

*Water molecules are not included.