6LPP

Crystal structure of human D-2-hydroxyglutarate dehydrogenase in complex with D-2-hydroxyglutarate (D-2-HG)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	D-2-hydroxyglutarate dehydrogenase, mitochondrial	polymer	481	52332.9	2	UniProt (Q8N465) Pfam (PF01565) Pfam (PF02913)	Homo sapiens (Human)
2	C, H (A, B)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	2	Chemie (FAD)
3	D, I (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	E, J (A, B)	(2R)-2-hydroxypentanedioic acid	non-polymer		148.1	2	Chemie (2HG)
5	F, G, K, L, M... (A, B)	GLYCEROL	non-polymer		92.1	7	Chemie (GOL)
6	P, Q (A, B)	water	water		18.0	103	Chemie (HOH)

Sequence modifications

A, B: 51 - 521 (UniProt: Q8N465)

PDB	External Database	Details
Gly 47	-	expression tag
Pro 48	-	expression tag
Gly 49	-	expression tag
Ser 50	-	expression tag
His 522	-	expression tag
His 523	-	expression tag
His 524	-	expression tag
His 525	-	expression tag
His 526	-	expression tag
His 527	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	104665.8
Non-Polymers*	Number of molecules	13
	Total formula weight	2642.8
All*	Total formula weight	107308.6

*Water molecules are not included.