6LN1
A natural inhibitor of DYRK1A for treatment of diabetes mellitus
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 347 | 40478.7 | 2 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,hMNB |
| 2 | C, D (A, B) | 1,3,5,8-tetrakis(oxidanyl)xanthen-9-one | non-polymer | 260.2 | 2 | Chemie (EKU) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 44 | Chemie (HOH) |
Sequence modifications
A, B: 135 - 480 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Phe 413 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80957.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 520.4 | |
| All* | Total formula weight | 81477.9 |
