6LKV

Structural and functional insights into macrophage migration inhibitory factor from Oncomelania hupensis, the intermediate host of Schistosoma japonicum

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (F)	Macrophage migration inhibitory factor	polymer	141	15986.6	1	UniProt (A0A1U9W5E8)	Oncomelania hupensis
2	B (A)	Macrophage migration inhibitory factor	polymer	138	15370.9	1	UniProt (A0A1U9W5E8)	Oncomelania hupensis
3	C (B)	Macrophage migration inhibitory factor	polymer	140	15915.5	1	UniProt (A0A1U9W5E8)	Oncomelania hupensis
4	D (C)	Macrophage migration inhibitory factor	polymer	138	15639.2	1	UniProt (A0A1U9W5E8)	Oncomelania hupensis
5	E, G (B, C)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
6	F (B)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
7	H, I, J, K (F, A, B, C)	water	water		18.0	424	Chemie (HOH)

Sequence modifications

F: 1 - 131 (UniProt: A0A1U9W5E8)

PDB	External Database	Details
Asn 89	Lys 89	See sequence details
Val 90	Ile 90	See sequence details
Ile 125	Asn 125	See sequence details
Tyr 132	-	expression tag
Leu 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag
Ala 141	-	expression tag

A: 1 - 131 (UniProt: A0A1U9W5E8)

PDB	External Database	Details
Asn 89	Lys 89	See sequence details
Val 90	Ile 90	See sequence details
Ile 125	Asn 125	See sequence details
Tyr 132	-	expression tag
Leu 133	-	expression tag
Ala 134	-	expression tag
Ala 135	-	expression tag
His 136	-	expression tag
Ala 137	-	expression tag
Ala 138	-	expression tag

B: 1 - 131 (UniProt: A0A1U9W5E8)

PDB	External Database	Details
Asn 89	Lys 89	See sequence details
Val 90	Ile 90	See sequence details
Ile 125	Asn 125	See sequence details
Tyr 132	-	expression tag
Leu 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag
His 139	-	expression tag
His 140	-	expression tag

C: 1 - 131 (UniProt: A0A1U9W5E8)

PDB	External Database	Details
Asn 89	Lys 89	See sequence details
Val 90	Ile 90	See sequence details
Ile 125	Asn 125	See sequence details
Tyr 132	-	expression tag
Leu 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
His 138	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	62912.1
Non-Polymers*	Number of molecules	3
	Total formula weight	167.0
All*	Total formula weight	63079.1

*Water molecules are not included.