6LJN
Crystal structure of human Sirt5 in complex with the fluorogenic tetrapeptide substrate P15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 272 | 29568.7 | 1 | UniProt (Q9NXA8) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 5,SIR2-like protein 5 |
| 2 | B (B) | ACE-HIS-PHE-SER-SLL | polymer | 5 | 644.7 | 1 | synthetic construct | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (B) | 7-AMINO-4-METHYL-CHROMEN-2-ONE | non-polymer | 175.2 | 1 | Chemie (MCM) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A: 34 - 302 (UniProt: Q9NXA8)
| PDB | External Database | Details |
|---|---|---|
| Gln 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Ser 33 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30213.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 240.6 | |
| All* | Total formula weight | 30454.0 |
