6LHJ
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with C452 (compound 16) and NADPH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 608 | 71908.1 | 2 | UniProt (D9N170) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | C, G (A, B) | 1-[3-(2-chloranyl-4-fluoranyl-phenoxy)propoxy]-6,6-dimethyl-1,3,5-triazine-2,4-diamine | non-polymer | 343.8 | 2 | Chemie (EA6) PubChem (154815512) | |||
| 3 | D, H (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | E, I (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) PubChem (688) PubChem (65063) PubChem (57164254) PubChem (446899) PubChem (446900) PubChem (71773959) PubChem (92144438) PubChem (92209480) PubChem (92209481) PubChem (92209482) PubChem (92449733) PubChem (133126534) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 708 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143816.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2886.9 | |
| All* | Total formula weight | 146703.1 |
