6LHI
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with C466 (compound 42) and NADPH
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 608 | 71908.1 | 2 | UniProt (D9N170) Pfam (PF00186) Pfam (PF00303) In PDB | Plasmodium falciparum (malaria parasite P. falciparum) | |
2 | A | METHIONINE | non-polymer | 149.2 | 1 | Chemie (MET) | |||
3 | A, B | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
4 | A, B | 1-[3-[(4-chlorophenyl)-(phenylmethyl)amino]propoxy]-6,6-dimethyl-1,3,5-triazine-2,4-diamine | non-polymer | 414.9 | 2 | Chemie (E9X) | |||
5 | A, B | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
6 | water | water | 18.0 | 96 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 143816.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 3086.3 | |
All* | Total formula weight | 146902.5 |