6LHD

Crystal structure of p53/BCL-xL fusion complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	fusion protein of Bcl-2-like protein 1 and Isoform 6 of Cellular tumor antigen p53	polymer	375	41859.7	2	UniProt (Q07817) UniProt (P04637) Pfam (PF02180) Pfam (PF00452) Pfam (PF00870) In PDB	Homo sapiens (Human)	Bcl2-L-1,Apoptosis regulator Bcl-X,Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3		water	water		18.0	105	Chemie (HOH)

Sequence modifications

A, B: 2 - 149 (UniProt: Q07817)

PDB	External Database	Details
Gly 0	-	expression tag
Pro 1	-	expression tag
-	Met 45	deletion
-	Glu 46	deletion
-	Thr 47	deletion
-	Pro 48	deletion
-	Ser 49	deletion
-	Ala 50	deletion
-	Ile 51	deletion
-	Asn 52	deletion
-	Gly 53	deletion
-	Asn 54	deletion
-	Pro 55	deletion
-	Ser 56	deletion
-	Trp 57	deletion
-	His 58	deletion
-	Leu 59	deletion
-	Ala 60	deletion
-	Asp 61	deletion
-	Ser 62	deletion
-	Pro 63	deletion
-	Ala 64	deletion
-	Val 65	deletion
-	Asn 66	deletion
-	Gly 67	deletion
-	Ala 68	deletion
-	Thr 69	deletion
-	Gly 70	deletion
-	His 71	deletion
-	Ser 72	deletion
-	Ser 73	deletion
-	Ser 74	deletion
-	Leu 75	deletion
-	Asp 76	deletion
-	Ala 77	deletion
-	Arg 78	deletion
-	Glu 79	deletion
-	Val 80	deletion
-	Ile 81	deletion
-	Pro 82	deletion
-	Met 83	deletion
-	Ala 84	deletion
Gly 149	-	linker
Gly 149	-	linker
Gly 149	-	linker
Gly 149	-	linker
Ser 149	-	linker
Leu 149	-	linker
Val 149	-	linker
Pro 149	-	linker
Arg 149	-	linker
Gly 149	-	linker
Ser 149	-	linker
Gly 149	-	linker
Gly 149	-	linker
Gly 149	-	linker
Gly 150	-	linker
Ser 150	-	linker

A, B: 162 - 358 (UniProt: P04637)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83719.5
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	83850.3

*Water molecules are not included.