6LD2

Zika NS5 polymerase domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RNA-directed RNA polymerase NS5	polymer	645	74904.2	1	UniProt (A0A024B7W1) Pfam (PF00972) Pfam (PF20483)	Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)	NS5
2	B, C (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D (A)	(1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid	non-polymer		270.3	1	Chemie (KY3)
4	E (A)	water	water		18.0	618	Chemie (HOH)

Sequence modifications

A: 270 - 891 (UniProt: A0A024B7W1)

PDB	External Database	Details
Met 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Ser 254	-	expression tag
Ser 255	-	expression tag
Gly 256	-	expression tag
Val 257	-	expression tag
Asp 258	-	expression tag
Leu 259	-	expression tag
Gly 260	-	expression tag
Thr 261	-	expression tag
Glu 262	-	expression tag
Asn 263	-	expression tag
Leu 264	-	expression tag
Tyr 265	-	expression tag
Phe 266	-	expression tag
Gln 267	-	expression tag
Ser 268	-	expression tag
Met 269	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	74904.2
Non-Polymers*	Number of molecules	3
	Total formula weight	401.2
All*	Total formula weight	75305.3

*Water molecules are not included.