6L6E
Human PDE5 catalytic core in complex with avanafil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 335 | 38990.9 | 1 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (Human) | human phosphodiesterase isoform 5,cGMP-binding cGMP-specific phosphodiesterase,CGB-PDE |
| 2 | B (A) | 4-[(3-chloranyl-4-methoxy-phenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimid ine-5-carboxamide | non-polymer | 484.0 | 1 | Chemie (E6L) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | F (A) | water | water | 18.0 | 87 | Chemie (HOH) |
Sequence modifications
A: 536 - 861 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Met 535 | - | initiating methionine |
| Leu 862 | - | expression tag |
| Glu 863 | - | expression tag |
| His 864 | - | expression tag |
| His 865 | - | expression tag |
| His 866 | - | expression tag |
| His 867 | - | expression tag |
| His 868 | - | expression tag |
| His 869 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38990.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 669.7 | |
| All* | Total formula weight | 39660.6 |
