6L50
Crystal structure of Zika NS2B-NS3 protease with compound 16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Serine protease subunit NS2B | polymer | 53 | 5865.4 | 4 | UniProt (Q32ZE1) Pfam (PF01002) | Zika virus (ZIKV) | NS2B cofactor |
| 2 | B, D, F, H (B, D, F, H) | NS3 protease | polymer | 178 | 19037.6 | 4 | UniProt (A0A142IX72) Pfam (PF00949) UniProt (by SIFTS) (Q32ZE1) | Zika virus (strain Mr 766) (ZIKV) | |
| 3 | I (H) | 2-sulfanylidene-1,3-thiazolidin-4-one | non-polymer | 133.2 | 1 | Chemie (E60) | |||
| 4 | J, K, L, M, N... (A, B, C, D, E...) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 46 - 96 (UniProt: Q32ZE1)
B, D, F, H: 1 - 177 (UniProt: A0A142IX72)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | initiating methionine |
| Thr 45 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 99611.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 133.2 | |
| All* | Total formula weight | 99745.1 |
