6L0C

Crystal structure of HIV-1 Integrase catalytic core domain (A128T/K173Q/F185K)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Integrase	polymer	170	18901.5	1	UniProt (Q76353) Pfam (PF00665) In PDB	Human immunodeficiency virus 1
2	A	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
3	A	ARSENIC	non-polymer		74.9	2	Chemie (ARS)
4		water	water		18.0	25	Chemie (HOH)

Sequence modifications

A: 50 - 212 (UniProt: Q76353)

PDB	External Database	Details
Met 43	-	initiating methionine
His 44	-	expression tag
His 45	-	expression tag
His 46	-	expression tag
His 47	-	expression tag
His 48	-	expression tag
His 49	-	expression tag
Thr 128	Ala 128	engineered mutation
Gln 173	Lys 173	engineered mutation
Lys 185	Phe 185	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	18901.5
Non-Polymers*	Number of molecules	6
	Total formula weight	534.1
All*	Total formula weight	19435.6

*Water molecules are not included.