6L04
Crystal structure of uPA_H99Y in complex with 31F
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | U | Urokinase-type plasminogen activator | polymer | 245 | 27611.4 | 1 | UniProt (P00749) Pfam (PF00089) In PDB | Homo sapiens (Human) | uPA |
| 2 | U | 3-azanyl-5-(azepan-1-yl)-N-carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide | non-polymer | 415.4 | 1 | Chemie (32I) | |||
| 3 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
U: 16 - 242 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Tyr 99 | His 272 | engineered mutation |
| Ala 122 | Cys 299 | engineered mutation |
| Gln 145 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27611.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 415.4 | |
| All* | Total formula weight | 28026.9 |
