6KX3
Crystal structure of RhoA protein with covalent inhibitor DC-Rhoin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Transforming protein RhoA | polymer | 181 | 20441.3 | 1 | UniProt (P61586) Pfam (PF00071) | Homo sapiens (Human) | RhoA protein, Rho cDNA clone 12,h12 |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | prop-2-enyl (3R)-1,1-bis(oxidanylidene)-2,3-dihydro-1-benzothiophene-3-carboxylate | non-polymer | 252.3 | 1 | Chemie (8ZO) | |||
| 4 | D (A) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A: 1 - 181 (UniProt: P61586)
| PDB | External Database | Details |
|---|---|---|
| Val 16 | Cys 16 | engineered mutation |
| Ser 20 | Cys 20 | engineered mutation |
| Val 83 | Cys 83 | engineered mutation |
| Thr 159 | Cys 159 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 20441.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 695.5 | |
| All* | Total formula weight | 21136.8 |
