6KTQ

Crystal structure of catalytic domain of homocitrate synthase from Sulfolobus acidocaldarius (SaHCS(dRAM)) in complex with alpha-ketoglutarate/Zn2+/CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Homocitrate synthase	polymer	412	45714.1	2	UniProt (Q4J989) Pfam (PF00682) Pfam (PF22617)	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)
2	C, L (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, M (A, B)	2-OXOGLUTARIC ACID	non-polymer		146.1	2	Chemie (AKG)
4	E, N (A, B)	COENZYME A	non-polymer		767.5	2	Chemie (COA)
5	F, G, I, J, K... (A, B)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
6	H (A)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
7	R, S (A, B)	water	water		18.0	343	Chemie (HOH)

Sequence modifications

A, B: 1 - 382 (UniProt: Q4J989)

PDB	External Database	Details
Met -21	-	expression tag
Lys -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Gly -11	-	expression tag
Gly -10	-	expression tag
Leu -9	-	expression tag
Val -8	-	expression tag
Pro -7	-	expression tag
Arg -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Leu 383	-	expression tag
Glu 384	-	expression tag
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	91428.1
Non-Polymers*	Number of molecules	15
	Total formula weight	2964.9
All*	Total formula weight	94393.0

*Water molecules are not included.