6KTL

Crystal structure of scyllo-inositol dehydrogenase R178A mutant, complexed with NAD and myo-inositol, from Paracoccus laeviglucosivorans

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Scyllo-inositol dehydrogenase with L-glucose dehydrogenase activity	polymer	380	41315.6	4	UniProt (K7ZP76)	Paracoccus laeviglucosivorans
2	E, H, J (A, B, C)	ACETATE ION	non-polymer		59.0	3	Chemie (ACT)
3	F, G, I, K (A, B, C, D)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	4	Chemie (NAD)
4	L (D)	1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE	non-polymer		180.2	1	Chemie (INS)
5	M, N, O, P (A, B, C, D)	water	water		18.0	1171	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 372 (UniProt: K7ZP76)

PDB	External Database	Details
Ser 72	Asn 72	See sequence details
Ala 178	Arg 178	engineered mutation
Leu 373	-	expression tag
Glu 374	-	expression tag
His 375	-	expression tag
His 376	-	expression tag
His 377	-	expression tag
His 378	-	expression tag
His 379	-	expression tag
His 380	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	165262.4
Non-Polymers*	Number of molecules	8
	Total formula weight	3011.0
All*	Total formula weight	168273.4

*Water molecules are not included.