6KPC

Crystal structure of an agonist bound GPCR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cannabinoid receptor 2,Endolysin	polymer	500	56209.9	1	UniProt (P34972) UniProt (A0A097J809) Pfam (PF00001) Pfam (PF00959) UniProt (by SIFTS) (P00720)	Homo sapiens (human)	hCB2,CX5,Lysis protein,Lysozyme,Muramidase
2	B (A)	7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile	non-polymer		399.6	1	Chemie (E3R)

Sequence modifications

A: 21 - 222 (UniProt: P34972)

PDB	External Database	Details
Met 2	-	initiating methionine
Lys 3	-	expression tag
Thr 4	-	expression tag
Ile 5	-	expression tag
Ile 6	-	expression tag
Ala 7	-	expression tag
Leu 8	-	expression tag
Ser 9	-	expression tag
Tyr 10	-	expression tag
Ile 11	-	expression tag
Phe 12	-	expression tag
Cys 13	-	expression tag
Leu 14	-	expression tag
Val 15	-	expression tag
Phe 16	-	expression tag
Ala 17	-	expression tag
Gly 18	-	expression tag
Ala 19	-	expression tag
Pro 20	-	expression tag
Leu 78	Gly 78	engineered mutation
Ala 127	Thr 127	engineered mutation
Leu 153	Thr 153	engineered mutation
Ala 210	Gly 210	engineered mutation

A: 1001 - 1160 (UniProt: A0A097J809)

PDB	External Database	Details
Thr 1053	Cys 54	engineered mutation
Ala 1096	Cys 97	engineered mutation

A: 235 - 325 (UniProt: P34972)

PDB	External Database	Details
Glu 242	Arg 242	engineered mutation
Glu 304	Gly 304	engineered mutation
Glu 326	-	expression tag
Phe 327	-	expression tag
Leu 328	-	expression tag
Glu 329	-	expression tag
Val 330	-	expression tag
Leu 331	-	expression tag
Phe 332	-	expression tag
Gln 333	-	expression tag
Gly 334	-	expression tag
Pro 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
His 340	-	expression tag
His 341	-	expression tag
His 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
Asp 346	-	expression tag
Tyr 347	-	expression tag
Lys 348	-	expression tag
Asp 349	-	expression tag
Asp 350	-	expression tag
Asp 351	-	expression tag
Asp 352	-	expression tag
Lys 353	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	56209.9
Non-Polymers*	Number of molecules	1
	Total formula weight	399.6
All*	Total formula weight	56609.5

*Water molecules are not included.