6KOT
Quadruple mutant (N51I+C59R+S108N+I164L) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with B12128 and NADPH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional dihydrofolate reductase-thymidylate synthase | polymer | 608 | 71908.1 | 2 | UniProt (D9N170) Pfam (PF00186) Pfam (PF00303) | Plasmodium falciparum (malaria parasite P. falciparum) | |
| 2 | C, F (A, B) | 4-[3-[[2,6-bis(azanyl)-5-(3-chlorophenyl)pyrimidin-4-yl]methoxy]phenoxy]butanoic acid | non-polymer | 428.9 | 2 | Chemie (DQ0) | |||
| 3 | D, G (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 4 | E, H (A, B) | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE | non-polymer | 308.2 | 2 | Chemie (UMP) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 316 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 143816.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 2964.9 | |
| All* | Total formula weight | 146781.2 |
