6KKU

human KCC1 structure determined in NaCl and GDN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Solute carrier family 12 member 4	polymer	1095	122054.9	2	UniProt (Q9UP95) Pfam (PF00324) Pfam (PF03522) In PDB	Homo sapiens (Human)	Electroneutral potassium-chloride cotransporter 1,Erythroid K-Cl cotransporter 1,hKCC1
2	C, D, G, H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
3	E, F, I, J	alpha-D-glucopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	4	In PDB BIRD (PRD_900018) GlyTouCan (G66120GK)		beta-maltose
4	A, B	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	A, B	2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol	non-polymer		516.8	2	Chemie (DU0)

Sequence modifications

A, B: 1 - 1085 (UniProt: Q9UP95)

PDB	External Database	Details
Leu 1086	-	expression tag
Glu 1087	-	expression tag
Trp 1088	-	expression tag
Ser 1089	-	expression tag
His 1090	-	expression tag
Pro 1091	-	expression tag
Gln 1092	-	expression tag
Phe 1093	-	expression tag
Glu 1094	-	expression tag
Lys 1095	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	244109.8
Branched	Number of molecules	8
	Total formula weight	3066.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1104.4
All*	Total formula weight	248281.0

*Water molecules are not included.