6KKE
THRb mutation with a novel agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Thyroid hormone receptor beta | polymer | 249 | 28117.7 | 1 | UniProt (P10828) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 1 group A member 2,c-erbA-2,c-erbA-beta |
| 2 | B (C) | SRC2-3 | polymer | 11 | 1349.6 | 1 | UniProt (by SIFTS) (Q15596) | Homo sapiens (Human) | |
| 3 | C (A) | 2-[(1-methyl-4-oxidanyl-7-phenoxy-isoquinolin-3-yl)carbonylamino]ethanoic acid | non-polymer | 352.3 | 1 | Chemie (8HO) | |||
| 4 | D, E (A, C) | water | water | 18.0 | 41 | Chemie (HOH) |
Sequence modifications
A: 211 - 459 (UniProt: P10828)
| PDB | External Database | Details |
|---|---|---|
| Leu 435 | His 435 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 29467.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 352.3 | |
| All* | Total formula weight | 29819.6 |
