6KGM

LSD1-CoREST-S2116 five-membered ring adduct model

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Lysine-specific histone demethylase 1A	polymer	669	74333.0	1	UniProt (O60341) Pfam (PF04433) Pfam (PF01593)	Homo sapiens (Human)	BRAF35-HDAC complex protein BHC110,Flavin-containing amine oxidase domain-containing protein 2
2	B (B)	REST corepressor 1	polymer	140	15850.9	1	UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249)	Homo sapiens (Human)	Protein CoREST
3	C, D, E, F, G (A)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
4	H (A)	3-[3,5-bis(fluoranyl)-2-phenylmethoxy-phenyl]propanal	non-polymer		276.3	1	Chemie (DJ0)
5	I (A)	FLAVIN-ADENINE DINUCLEOTIDE	non-polymer		785.5	1	Chemie (FAD)
6	J (A)	water	water		18.0	54	Chemie (HOH)

Sequence modifications

A: 172 - 833 (UniProt: O60341)

PDB	External Database	Details
Gly 165	-	expression tag
Pro 166	-	expression tag
Leu 167	-	expression tag
Gly 168	-	expression tag
Ser 169	-	expression tag
His 170	-	expression tag
Met 171	-	expression tag

B: 308 - 440 (UniProt: Q9UKL0)

PDB	External Database	Details
Gly 301	-	expression tag
Ser 302	-	expression tag
Ser 303	-	expression tag
Gly 304	-	expression tag
Ser 305	-	expression tag
Ala 306	-	expression tag
Ser 307	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90184.0
Non-Polymers*	Number of molecules	7
	Total formula weight	1522.3
All*	Total formula weight	91706.3

*Water molecules are not included.