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6KDZ

Crystal structure of PDE10A in complex with a triazolopyrimidine inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10Apolymer34539606.42UniProt (Q9Y233)
In PDB
Homo sapiens (Human)
2A, BZINC IONnon-polymer65.42Chemie (ZN)
3A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
4A4-[2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)ethyl]-3,7,8,10-tetrazatricyclo[7.4.0.0^{2,7}]trideca-1,3,5,8,10,12-hexaen-6-olnon-polymer360.41Chemie (D79)
Sequence modifications
A, B: 449 - 789 (UniProt: Q9Y233)
PDBExternal DatabaseDetails
Gly 445-expression tag
Ser 446-expression tag
His 447-expression tag
Met 448-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight79212.9
Non-Polymers*Number of molecules5
Total formula weight539.8
All*Total formula weight79752.7
*Water molecules are not included.

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PDB entries from 2024-09-11

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