6K9H

Human LXR-beta in complex with an agonist

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Oxysterols receptor LXR-beta	polymer	274	31171.6	2	UniProt (P55055) Pfam (PF00104)	Homo sapiens (Human)	Liver X receptor beta,Nuclear receptor NER,Nuclear receptor subfamily 1 group H member 2,Ubiquitously-expressed nuclear receptor
2	C, D (A, B)	~{tert}-butyl (2'~{S},3~{S})-2-oxidanylidene-2'-phenyl-spiro[1~{H}-indole-3,3'-pyrrolidine]-1'-carboxylate	non-polymer		364.4	2	Chemie (D40)
3	E, F (A, B)	water	water		18.0	14	Chemie (HOH)

Sequence modifications

A, B: 215 - 461 (UniProt: P55055)

PDB	External Database	Details
Met 207	-	initiating methionine
Gly 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag
His 212	-	expression tag
His 213	-	expression tag
His 214	-	expression tag
Ala 259	Gln 258	engineered mutation
Gly 261	Arg 260	engineered mutation
Ser 262	Asp 261	engineered mutation
Ser 264	Arg 263	engineered mutation
Gly 462	-	expression tag
Ser 463	-	expression tag
Gly 464	-	expression tag
Ser 465	-	expression tag
Gly 466	-	expression tag
Ser 467	-	expression tag
His 468	-	expression tag
Lys 469	-	expression tag
Ile 470	-	expression tag
Leu 471	-	expression tag
His 472	-	expression tag
Arg 473	-	expression tag
Leu 474	-	expression tag
Leu 475	-	expression tag
Gln 476	-	expression tag
Asp 477	-	expression tag
Ser 478	-	expression tag
Ser 479	-	expression tag
Ser 480	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	62343.2
Non-Polymers*	Number of molecules	2
	Total formula weight	728.9
All*	Total formula weight	63072.1

*Water molecules are not included.