6K7K
Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ADP-Pi state)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phospholipid-transporting ATPase | polymer | 1154 | 130537.9 | 1 | UniProt (Q59EX4) Pfam (PF16209) Pfam (PF00122) Pfam (PF13246) Pfam (PF16212) UniProt (by SIFTS) (Q9Y2Q0) In PDB | Homo sapiens (Human) | |
2 | C | Cell cycle control protein 50A | polymer | 361 | 40727.5 | 1 | UniProt (Q9NV96) Pfam (PF03381) In PDB | Homo sapiens (Human) | |
3 | B | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
4 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
5 | A | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 1 | Chemie (ALF) | |||
6 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
7 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
8 | C | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 1 | Chemie (Y01) |
Sequence modifications
A: 1 - 1149 (UniProt: Q59EX4)
PDB | External Database | Details |
---|---|---|
Gly -4 | - | expression tag |
Ser -3 | - | expression tag |
Arg -2 | - | expression tag |
Glu -1 | - | expression tag |
Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 171265.4 | |
Branched | Number of molecules | 1 |
Total formula weight | 586.5 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1507.9 | |
All* | Total formula weight | 173359.8 |