6K1K

Human nucleosome core particle with H2A.X S139E variant

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3.1	polymer	139	15719.4	2	UniProt (P68431) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H3/a,Histone H3/b,Histone H3/c,Histone H3/d,Histone H3/f,Histone H3/h,Histone H3/i,Histone H3/j,Histone H3/k,Histone H3/l
2	B, F	Histone H4	polymer	106	11676.7	2	UniProt (P62805) Pfam (PF15511) In PDB	Homo sapiens (Human)
3	C, G	Histone H2AX	polymer	146	15496.9	2	UniProt (P16104) Pfam (PF00125) Pfam (PF16211) In PDB	Homo sapiens (Human)	H2a/x,Histone H2A.X
4	D, H	Histone H2B type 1-J	polymer	129	14217.5	2	UniProt (P06899) Pfam (PF00125) In PDB	Homo sapiens (Human)	Histone H2B.1,Histone H2B.r,H2B/r
5	I	DNA (145-MER)	polymer	145	44761.5	1		Homo sapiens
6	J	DNA (145-MER)	polymer	145	44752.5	1		Homo sapiens
7	C, G	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
8	I, J, H	MANGANESE (II) ION	non-polymer		54.9	33	Chemie (MN)
9	I, J	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
10		water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, E: 0 - 135 (UniProt: P68431)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

B, F: 0 - 102 (UniProt: P62805)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag

C, G: 0 - 142 (UniProt: P16104)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Glu 139	Ser 140	variant

D, H: -3 - 122 (UniProt: P06899)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
His -4	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	203735.2
Non-Polymers*	Number of molecules	37
	Total formula weight	1962.1
All*	Total formula weight	205697.2

*Water molecules are not included.