6JXR
Structure of human T cell receptor-CD3 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (a, b) | T-cell surface glycoprotein CD3 zeta chain | polymer | 164 | 18723.4 | 2 | UniProt (P20963) Pfam (PF11628) Pfam (PF02189) | Homo sapiens (Human) | T-cell receptor T3 zeta chain |
| 2 | C (d) | T-cell surface glycoprotein CD3 delta chain | polymer | 171 | 18949.5 | 1 | UniProt (P04234) Pfam (PF16680) Pfam (PF02189) | Homo sapiens (Human) | T-cell receptor T3 delta chain |
| 3 | D, H (f, e) | T-cell surface glycoprotein CD3 epsilon chain | polymer | 207 | 23174.2 | 2 | UniProt (P07766) Pfam (PF16681) Pfam (PF02189) | Homo sapiens (Human) | T-cell surface antigen T3/Leu-4 epsilon chain |
| 4 | E (g) | T-cell surface glycoprotein CD3 gamma chain | polymer | 182 | 20493.5 | 1 | UniProt (P09693) Pfam (PF16680) Pfam (PF02189) | Homo sapiens (Human) | T-cell receptor T3 gamma chain |
| 5 | F (m) | T cell receptor alpha variable 12-3,Possible J 11 gene segment,T cell receptor alpha constant | polymer | 252 | 28308.7 | 1 | UniProt (A0A0B4J271) UniProt (A0N4Z6) UniProt (P01848) Pfam (PF07686) Pfam (PF09291) | Homo sapiens (Human) | |
| 6 | G (n) | T cell receptor beta variable 6-5,M1-specific T cell receptor beta chain,T cell receptor beta constant 2 | polymer | 291 | 32498.5 | 1 | UniProt (A0A0G2JMB4) UniProt (A0A0K0K1A5) UniProt (P0DSE2) Pfam (PF07686) Pfam (PF07654) | Homo sapiens (Human) | TR beta chain TRBV19*01J2S7*01C*02 |
Sequence modifications
m: 22 - 114 (UniProt: A0A0B4J271)
m: 116 - 132 (UniProt: A0N4Z6)
m: 134 - 273 (UniProt: P01848)
n: 22 - 112 (UniProt: A0A0K0K1A5)
n: 121 - 134 (UniProt: P0DSE2)
n: 135 - 312 (UniProt: A0A0G2JMB4)
| PDB | External Database | Details |
|---|---|---|
| Lys 115 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Asp 133 | - | linker |
n: 22 - 112 (UniProt: A0A0K0K1A5)
| PDB | External Database | Details |
|---|---|---|
| Arg 113 | - | linker |
| Arg 114 | - | linker |
| Arg 115 | - | linker |
| Gln 116 | - | linker |
| Gly 117 | - | linker |
| Ala 118 | - | linker |
| Ser 119 | - | linker |
| Gly 120 | - | linker |
n: 135 - 312 (UniProt: A0A0G2JMB4)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 184045.5 | |
| All* | Total formula weight | 184045.5 |
