6JWN

Crystal structure of the SPRY domain of SPSB2 in complex with cR9, a cyclic peptide inhibitor of SPSB-iNOS interaction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	SPRY domain-containing SOCS box protein 2	polymer	209	22896.6	2	UniProt (Q99619) Pfam (PF00622)	Homo sapiens (Human)	SSB-2,Gene-rich cluster protein C9
2	B, D (B, D)	Nitric oxide synthase, inducible	polymer	9	1031.1	2	UniProt (P35228)	Homo sapiens	cR9 peptide
3	E, F, G, H (A, B, C, D)	water	water		18.0	137	Chemie (HOH)

Sequence modifications

A, C: 22 - 220 (UniProt: Q99619)

PDB	External Database	Details
Met 20	-	expression tag
Gly 21	-	expression tag
Gly 221	-	expression tag
Ser 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag

B, D: 1 - 9 (UniProt: P35228)

PDB	External Database	Details
Arg 1	Glu 21	conflict
Gly 2	Lys 22	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	47855.3
All*	Total formula weight	47855.3

*Water molecules are not included.