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6JWM

Crystal structure of the SPRY domain of SPSB2 in complex with cR7, a potent cyclic peptide inhibitor of SPSB2-iNOS interaction

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
SPRY domain-containing SOCS box protein 2polymer20922896.61UniProt (Q99619)
Pfam (PF00622)
Homo sapiens (Human)SSB-2,Gene-rich cluster protein C9
2B
(B)
Nitric oxide synthase, induciblepolymer7802.81UniProt (P35228)Homo sapiensHepatocyte NOS,HEP-NOS,Inducible NO synthase,iNOS,NOS type II,Peptidyl-cysteine S-nitrosylase NOS2
3C, D
(A, B)
waterwater18.0125Chemie (HOH)
Sequence modifications
A: 22 - 220 (UniProt: Q99619)
PDBExternal DatabaseDetails
Met 20-expression tag
Gly 21-expression tag
Gly 221-expression tag
Ser 222-expression tag
His 223-expression tag
His 224-expression tag
His 225-expression tag
His 226-expression tag
His 227-expression tag
His 228-expression tag
B: 1 - 7 (UniProt: P35228)
PDBExternal DatabaseDetails
Arg 1Glu 21conflict
Gly 2Lys 22conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight23699.4
All*Total formula weight23699.4
*Water molecules are not included.

238895

PDB entries from 2025-07-16

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