6JW8
The crystal structure of KanD2 in complex with NADH and 3"-deamino-3"-hydroxykanamycin B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dehydrogenase | polymer | 386 | 41108.1 | 2 | UniProt (Q6L737) Pfam (PF01408) Pfam (PF22725) | Streptomyces kanamyceticus | KanD2 |
| 2 | C, E (A, B) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 2 | Chemie (NAI) | |||
| 3 | D (A) | (2S,3R,4S,5S,6R)-2-[(1S,2S,3R,4S,6R)-3-[(2R,3R,4R,5S,6R)-6-(aminomethyl)-3-azanyl-4,5-bis(oxidanyl)oxan-2-yl]oxy-4,6-bis(azanyl)-2-oxidanyl-cyclohexyl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol | non-polymer | 484.5 | 1 | Chemie (CK0) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 373 (UniProt: Q6L737)
| PDB | External Database | Details |
|---|---|---|
| Lys 374 | - | expression tag |
| Leu 375 | - | expression tag |
| Ala 376 | - | expression tag |
| Ala 377 | - | expression tag |
| Ala 378 | - | expression tag |
| Leu 379 | - | expression tag |
| Glu 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| His 386 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82216.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1815.4 | |
| All* | Total formula weight | 84031.5 |
