6JQR
Crystal structure of FLT3 in complex with gilteritinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Receptor-type tyrosine-protein kinase FLT3,Receptor-type tyrosine-protein kinase FLT3 | polymer | 330 | 37999.2 | 1 | UniProt (P36888) Pfam (PF07714) In PDB | Homo sapiens | FL cytokine receptor,Fetal liver kinase-2,FLK-2,Fms-like tyrosine kinase 3,FLT-3,Stem cell tyrosine kinase 1,STK-1 |
2 | A | 6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide | non-polymer | 552.7 | 1 | Chemie (C6F) | |||
3 | A | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
5 | A | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID | non-polymer | 221.3 | 1 | Chemie (CXS) | |||
6 | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 37999.2 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1338.5 | |
All* | Total formula weight | 39337.7 |