6JPB
Rabbit Cav1.1-Diltiazem Complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Voltage-dependent L-type calcium channel subunit alpha-1S | polymer | 1873 | 212240.6 | 1 | UniProt (P07293) Pfam (PF00520) Pfam (PF08016) Pfam (PF16905) Pfam (PF08763) Pfam (PF16885) In PDB | Oryctolagus cuniculus (Rabbit) | Calcium channel,L type,alpha-1 polypeptide,isoform 3,skeletal muscle,Voltage-gated calcium channel subunit alpha Cav1.1 |
| 2 | E | Voltage-dependent calcium channel gamma-1 subunit | polymer | 222 | 25082.3 | 1 | UniProt (P19518) Pfam (PF13903) In PDB | Oryctolagus cuniculus (Rabbit) | Dihydropyridine-sensitive L-type,skeletal muscle calcium channel subunit gamma |
| 3 | B | Voltage-dependent L-type calcium channel subunit beta-1 | polymer | 450 | 49642.4 | 1 | UniProt (P19517) Pfam (PF12052) Pfam (PF00625) In PDB | Oryctolagus cuniculus (Rabbit) | CAB1,Calcium channel voltage-dependent subunit beta 1 |
| 4 | C | Voltage-dependent L-type calcium channel subunit beta-1 | polymer | 524 | 57898.3 | 1 | UniProt (P19517) Pfam (PF12052) Pfam (PF00625) In PDB | Oryctolagus cuniculus (Rabbit) | CAB1,Calcium channel voltage-dependent subunit beta 1 |
| 5 | F | Voltage-dependent calcium channel subunit alpha-2/delta-1 | polymer | 1046 | 118641.4 | 1 | UniProt (P13806) Pfam (PF08399) Pfam (PF00092) Pfam (PF08473) In PDB | Oryctolagus cuniculus (Rabbit) | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| 6 | D, G, J, K | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G79924RM) | |||
| 7 | H, I | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 8 | L | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 627.6 | 1 | In PDB GlyTouCan (G11411VI) | |||
| 9 | F, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 10 | A, F | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 11 | A | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 4 | Chemie (3PE) | |||
| 12 | A | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 1 | Chemie (PC1) | |||
| 13 | A | Diltiazem | non-polymer | 414.5 | 1 | Chemie (C9F) | |||
| 14 | F | ETHANOLAMINE | non-polymer | 61.1 | 1 | Chemie (ETA) |
Sequence modifications
B: 80 - 524 (UniProt: P19517)
F: 27 - 1047 (UniProt: P13806)
| PDB | External Database | Details |
|---|---|---|
| Gln 75 | - | expression tag |
| Gly 76 | - | expression tag |
| Pro 77 | - | expression tag |
| His 78 | - | expression tag |
| Met 79 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| - | Ser 620 | See sequence details |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 463505.0 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3498.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 6147.9 | |
| All* | Total formula weight | 473151.1 |
