6JKA
Crystal structure of metallo-beta-lactamse, IMP-1, in complex with a thiazole-bearing inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Metallo-beta-lactamase type 2 | polymer | 228 | 25015.5 | 4 | UniProt (P52699) Pfam (PF00753) | Serratia marcescens | B2 metallo-beta-lactamase,BLA-IMP,IMP-1,Beta-lactamase type II,Metallo-beta-lactamase type II |
| 2 | E, F, H, I, K... (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 3 | G, M (A, C) | 6-[2-(phenoxymethyl)-1,3-thiazol-4-yl]-3,4-dihydro-1H-quinolin-2-one | non-polymer | 336.4 | 2 | Chemie (BS0) | |||
| 4 | J (B) | 3-[2-azanyl-5-[2-(phenoxymethyl)-1,3-thiazol-4-yl]phenyl]propanoic acid | non-polymer | 354.4 | 1 | Chemie (BQU) | |||
| 5 | P, Q, R, S (A, B, C, D) | water | water | 18.0 | 363 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 6 - 228 (UniProt: P52699)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Pro 2 | - | expression tag |
| Gly 3 | - | expression tag |
| Val 4 | - | expression tag |
| Gly 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 100062.1 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1550.5 | |
| All* | Total formula weight | 101612.6 |
