6J3B
Crystal structure of human DHODH in complex with inhibitor 1289
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Dihydroorotate dehydrogenase (quinone), mitochondrial | polymer | 366 | 39725.3 | 1 | UniProt (Q02127) Pfam (PF01180) In PDB | Homo sapiens (Human) | DHOdehase,Dihydroorotate oxidase |
| 2 | A | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 3 | A | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) | |||
| 4 | A | OROTIC ACID | non-polymer | 156.1 | 1 | Chemie (ORO) | |||
| 5 | A | (6R)-1-[3,5-bis(fluoranyl)-4-[2-fluoranyl-5-(hydroxymethyl)phenyl]phenyl]-6-propan-2-yl-6,7-dihydro-5H-benzotriazol-4-one | non-polymer | 415.4 | 1 | Chemie (B5O) | |||
| 6 | A | LAURYL DIMETHYLAMINE-N-OXIDE | non-polymer | 229.4 | 1 | Chemie (LDA) | |||
| 7 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 8 | A | ACETATE ION | non-polymer | 59.0 | 6 | Chemie (ACT) | |||
| 9 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 10 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 11 | water | water | 18.0 | 326 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39725.3 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2496.5 | |
| All* | Total formula weight | 42221.8 |
