6IYC
Recognition of the Amyloid Precursor Protein by Human gamma-secretase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nicastrin | polymer | 709 | 78483.6 | 1 | UniProt (Q92542) Pfam (PF18266) Pfam (PF05450) | Homo sapiens (Human) | |
| 2 | B (B) | Presenilin-1 | polymer | 467 | 52688.6 | 1 | UniProt (P49768) Pfam (PF01080) | Homo sapiens (Human) | PS-1,Protein S182 |
| 3 | C (C) | Gamma-secretase subunit APH-1A | polymer | 265 | 29017.9 | 1 | UniProt (Q96BI3) Pfam (PF06105) | Homo sapiens (Human) | APH-1a,Aph-1alpha,Presenilin-stabilization factor |
| 4 | D (D) | Gamma-secretase subunit PEN-2 | polymer | 101 | 12038.0 | 1 | UniProt (Q9NZ42) Pfam (PF10251) | Homo sapiens (Human) | Presenilin enhancer protein 2 |
| 5 | E (E) | Amyloid-beta A4 protein | polymer | 104 | 11888.6 | 1 | UniProt (P05067) Pfam (PF03494) Pfam (PF10515) | Homo sapiens (Human) | ABPP,APPI,APP,Alzheimer disease amyloid protein,Amyloid precursor protein,Amyloid-beta precursor protein,Cerebral vascular amyloid peptide,CVAP,PreA4,Protease nexin-II,PN-II |
| 6 | F, H, I, J, K (F, H, I, J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G (G) | beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G89225LT) | |||
| 8 | L, M, N, O, P... (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 9 | R, V (B, C) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 2 | Chemie (PC1) | |||
| 10 | S, T, U (C) | CHOLESTEROL | non-polymer | 386.7 | 3 | Chemie (CLR) |
Sequence modifications
B: 1 - 467 (UniProt: P49768)
E: 1 - 83 (UniProt: P05067)
| PDB | External Database | Details |
|---|---|---|
| Cys 112 | Gln 112 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| Cys 8 | Val 695 | engineered mutation |
| Glu 84 | - | expression tag |
| Gln 85 | - | expression tag |
| Lys 86 | - | expression tag |
| Leu 87 | - | expression tag |
| Ile 88 | - | expression tag |
| Ser 89 | - | expression tag |
| Glu 90 | - | expression tag |
| Glu 91 | - | expression tag |
| Asp 92 | - | expression tag |
| Leu 93 | - | expression tag |
| Leu 94 | - | expression tag |
| Glu 95 | - | expression tag |
| His 96 | - | expression tag |
| His 97 | - | expression tag |
| His 98 | - | expression tag |
| His 99 | - | expression tag |
| His 100 | - | expression tag |
| His 101 | - | expression tag |
| His 102 | - | expression tag |
| His 103 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 184116.7 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 3032.8 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 4067.5 | |
| All* | Total formula weight | 191217.0 |
