6IQL
Crystal structure of dopamine receptor D4 bound to the subtype-selective ligand, L745870
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | D(4) dopamine receptor,Soluble cytochrome b562,D(4) dopamine receptor | polymer | 396 | 43565.7 | 2 | UniProt (P51436) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Mus musculus (Mouse) | D(2C) dopamine receptor,Dopamine D4 receptor,Cytochrome b-562 |
2 | A, B | 3-{[4-(4-chlorophenyl)piperazin-1-yl]methyl}-1H-pyrrolo[2,3-b]pyridine | non-polymer | 326.8 | 2 | Chemie (L74) |
Sequence modifications
A, B: 23 - 218 (UniProt: P51436)
A, B: 1001 - 1105 (UniProt: P0ABE7)
A, B: 304 - 387 (UniProt: P51436)
PDB | External Database | Details |
---|---|---|
Asp 13 | - | expression tag |
Tyr 14 | - | expression tag |
Lys 15 | - | expression tag |
Asp 16 | - | expression tag |
Asp 17 | - | expression tag |
Asp 18 | - | expression tag |
Asp 19 | - | expression tag |
Lys 20 | - | expression tag |
Glu 21 | - | expression tag |
Phe 22 | - | expression tag |
Trp 121 | Phe 121 | engineered mutation |
Arg 181 | Cys 181 | engineered mutation |
Ile 201 | Pro 201 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Leu 1106 | - | linker |
PDB | External Database | Details |
---|---|---|
Ala 317 | Pro 317 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 87131.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 653.6 | |
All* | Total formula weight | 87785.0 |