6IQL

Crystal structure of dopamine receptor D4 bound to the subtype-selective ligand, L745870

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	D(4) dopamine receptor,Soluble cytochrome b562,D(4) dopamine receptor	polymer	396	43565.7	2	UniProt (P51436) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361)	Mus musculus (Mouse)	D(2C) dopamine receptor,Dopamine D4 receptor,Cytochrome b-562
2	C, D (A, B)	3-{[4-(4-chlorophenyl)piperazin-1-yl]methyl}-1H-pyrrolo[2,3-b]pyridine	non-polymer		326.8	2	Chemie (L74)

Sequence modifications

A, B: 23 - 218 (UniProt: P51436)

PDB	External Database	Details
Asp 13	-	expression tag
Tyr 14	-	expression tag
Lys 15	-	expression tag
Asp 16	-	expression tag
Asp 17	-	expression tag
Asp 18	-	expression tag
Asp 19	-	expression tag
Lys 20	-	expression tag
Glu 21	-	expression tag
Phe 22	-	expression tag
Trp 121	Phe 121	engineered mutation
Arg 181	Cys 181	engineered mutation
Ile 201	Pro 201	engineered mutation

A, B: 1001 - 1105 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	engineered mutation
Ile 1102	His 124	engineered mutation
Leu 1106	-	linker

A, B: 304 - 387 (UniProt: P51436)

PDB	External Database	Details
Ala 317	Pro 317	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87131.4
Non-Polymers*	Number of molecules	2
	Total formula weight	653.6
All*	Total formula weight	87785.0

*Water molecules are not included.