6IMT
Crystal structure of PDE4D complexed with a novel inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 349 | 40096.4 | 2 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (Human) | PDE4D, DPDE3,PDE43 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
4 | A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
5 | A, B | (1S)-1-[2-(6-fluoro-1H-indol-3-yl)ethyl]-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-carbaldehyde | non-polymer | 382.4 | 2 | Chemie (AK0) | |||
6 | water | water | 18.0 | 398 | Chemie (HOH) |
Sequence modifications
A, B: 86 - 413 (UniProt: Q08499)
PDB | External Database | Details |
---|---|---|
Met 65 | - | expression tag |
Gly 66 | - | expression tag |
Ser 67 | - | expression tag |
Ser 68 | - | expression tag |
His 69 | - | expression tag |
His 70 | - | expression tag |
His 71 | - | expression tag |
His 72 | - | expression tag |
His 73 | - | expression tag |
His 74 | - | expression tag |
Ser 75 | - | expression tag |
Ser 76 | - | expression tag |
Gly 77 | - | expression tag |
Leu 78 | - | expression tag |
Val 79 | - | expression tag |
Pro 80 | - | expression tag |
Arg 81 | - | expression tag |
Gly 82 | - | expression tag |
Ser 83 | - | expression tag |
His 84 | - | expression tag |
Met 85 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 80192.7 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 1565.0 | |
All* | Total formula weight | 81757.7 |