6ILZ
Crystal structure of PKCiota in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, C, E, G) | Protein kinase C iota type | polymer | 345 | 39854.8 | 4 | UniProt (P41743) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (Human) | Atypical protein kinase C-lambda/iota,aPKC-lambda/iota,nPKC-iota |
| 2 | E, F, G, H (A, C, E, G) | 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl)pyridine-3-carboxamide | non-polymer | 374.4 | 4 | Chemie (AFU) |
Sequence modifications
A, C, E, G: 249 - 588 (UniProt: P41743)
| PDB | External Database | Details |
|---|---|---|
| Gly 244 | - | expression tag |
| Ala 245 | - | expression tag |
| Met 246 | - | expression tag |
| Asp 247 | - | expression tag |
| Pro 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 159419.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1497.8 | |
| All* | Total formula weight | 160917.0 |
