6IIU
Crystal structure of the human thromboxane A2 receptor bound to ramatroban
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor | polymer | 484 | 53242.2 | 1 | UniProt (P0ABE7) UniProt (P21731) UniProt (P00268) Pfam (PF07361) Pfam (PF00001) Pfam (PF00301) In PDB | Escherichia coli | Cytochrome b-562,TXA2-R,Prostanoid TP receptor,Rd,TXA2-R,Prostanoid TP receptor |
2 | A | 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid | non-polymer | 416.5 | 1 | Chemie (A8X) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) | |||
5 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) | |||
6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
7 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1106 (UniProt: P0ABE7)
A: 10 - 228 (UniProt: P21731)
A: 2001 - 2054 (UniProt: P00268)
A: 237 - 323 (UniProt: P21731)
PDB | External Database | Details |
---|---|---|
Asp 991 | - | expression tag |
Tyr 992 | - | expression tag |
Lys 993 | - | expression tag |
Asp 994 | - | expression tag |
Asp 995 | - | expression tag |
Asp 996 | - | expression tag |
Asp 997 | - | expression tag |
Gly 998 | - | expression tag |
Ala 999 | - | expression tag |
Pro 1000 | - | expression tag |
Trp 1007 | Met 29 | engineered mutation |
Ile 1102 | His 124 | engineered mutation |
Leu 1106 | Arg 128 | engineered mutation |
A: 2001 - 2054 (UniProt: P00268)
A: 237 - 323 (UniProt: P21731)
PDB | External Database | Details |
---|---|---|
Ala 247 | Leu 247 | engineered mutation |
Glu 324 | - | expression tag |
Phe 325 | - | expression tag |
Leu 326 | - | expression tag |
Glu 327 | - | expression tag |
Val 328 | - | expression tag |
Leu 329 | - | expression tag |
Phe 330 | - | expression tag |
Gln 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 53242.2 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 1673.7 | |
All* | Total formula weight | 54915.9 |