6IIU
Crystal structure of the human thromboxane A2 receptor bound to ramatroban
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Soluble cytochrome b562,Thromboxane A2 receptor,Rubredoxin,Thromboxane A2 receptor | polymer | 484 | 53242.2 | 1 | UniProt (P0ABE7) UniProt (P21731) UniProt (P00268) Pfam (PF00001) | Escherichia coli | Cytochrome b-562,TXA2-R,Prostanoid TP receptor,Rd,TXA2-R,Prostanoid TP receptor |
| 2 | B (A) | 3-[(3R)-3-[(4-fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid | non-polymer | 416.5 | 1 | Chemie (A8X) PubChem (5036) PubChem (123879) PubChem (25273225) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (16219173) PubChem (16758052) PubChem (304) PubChem (176980071) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (45044259) PubChem (23423981) PubChem (49853509) PubChem (50990013) PubChem (52934537) PubChem (56621683) PubChem (191463) PubChem (57915018) PubChem (57939063) PubChem (58428240) PubChem (58445498) PubChem (58663286) PubChem (368063) PubChem (369319) PubChem (44654663) PubChem (59450329) PubChem (59628412) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (46937002) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (638019) PubChem (59274407) PubChem (1549081) PubChem (1553803) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (89951918) PubChem (90224410) PubChem (5997) PubChem (5283629) PubChem (5284644) PubChem (1551269) PubChem (90070115) PubChem (91298236) PubChem (5315842) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (6419195) PubChem (10861996) PubChem (132837164) PubChem (101624109) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (124225449) PubChem (138967089) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (139566851) PubChem (124429284) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (15939944) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (171828367) PubChem (173516975) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 5 | E, F (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 2 | Chemie (OLC) PubChem (25021708) PubChem (46840179) PubChem (54294271) PubChem (54294270) PubChem (33022) PubChem (5283468) PubChem (5364833) PubChem (11451146) PubChem (12178130) | |||
| 6 | G (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 7 | H (A) | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1106 (UniProt: P0ABE7)
A: 10 - 228 (UniProt: P21731)
A: 2001 - 2054 (UniProt: P00268)
A: 237 - 323 (UniProt: P21731)
| PDB | External Database | Details |
|---|---|---|
| Asp 991 | - | expression tag |
| Tyr 992 | - | expression tag |
| Lys 993 | - | expression tag |
| Asp 994 | - | expression tag |
| Asp 995 | - | expression tag |
| Asp 996 | - | expression tag |
| Asp 997 | - | expression tag |
| Gly 998 | - | expression tag |
| Ala 999 | - | expression tag |
| Pro 1000 | - | expression tag |
| Trp 1007 | Met 29 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Leu 1106 | Arg 128 | engineered mutation |
A: 2001 - 2054 (UniProt: P00268)
A: 237 - 323 (UniProt: P21731)
| PDB | External Database | Details |
|---|---|---|
| Ala 247 | Leu 247 | engineered mutation |
| Glu 324 | - | expression tag |
| Phe 325 | - | expression tag |
| Leu 326 | - | expression tag |
| Glu 327 | - | expression tag |
| Val 328 | - | expression tag |
| Leu 329 | - | expression tag |
| Phe 330 | - | expression tag |
| Gln 331 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 53242.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1673.7 | |
| All* | Total formula weight | 54915.9 |
