6IGL
Crystal Structure of human ETB receptor in complex with IRL1620
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endothelin receptor type B,Endolysin,Endothelin receptor type B | polymer | 498 | 55956.7 | 1 | UniProt (P24530) UniProt (A0A097J809) Pfam (PF00001) | Homo sapiens (Human) | ET-BR,Endothelin receptor non-selective type,Lysis protein,Lysozyme,Muramidase |
| 2 | B (B) | IRL1620 | polymer | 15 | 1822.0 | 1 | Homo sapiens | ||
| 3 | C (A) | CITRIC ACID | non-polymer | 192.1 | 1 | Chemie (CIT) | |||
| 4 | D, E, F, G (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | H, I, J (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 3 | Chemie (OLC) | |||
| 6 | K (A) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A: 66 - 303 (UniProt: P24530)
A: 1000 - 1159 (UniProt: A0A097J809)
A: 311 - 407 (UniProt: P24530)
| PDB | External Database | Details |
|---|---|---|
| Gly 63 | - | expression tag |
| Gly 64 | - | expression tag |
| Gly 65 | - | expression tag |
| Tyr 124 | Arg 124 | engineered mutation |
| Ala 154 | Asp 154 | engineered mutation |
| Ala 270 | Lys 270 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Thr 1052 | Cys 54 | engineered mutation |
| Ala 1095 | Cys 97 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 342 | Ser 342 | engineered mutation |
| Ala 381 | Ile 381 | engineered mutation |
| Ala 396 | Cys 396 | engineered mutation |
| Ala 400 | Cys 400 | engineered mutation |
| Ala 405 | Cys 405 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57778.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1646.0 | |
| All* | Total formula weight | 59424.7 |
