6IF2

Complex structure of Rab35 and its effector RUSC2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (B)	Ras-related protein Rab-35	polymer	186	21095.9	1	UniProt (Q15286) Pfam (PF00071)	Homo sapiens (Human)	GTP-binding protein RAY,Ras-related protein Rab-1C
2	B (A)	Iporin	polymer	205	22759.4	1	UniProt (Q8N2Y8) Pfam (PF02759)	Homo sapiens (Human)	Interacting protein of Rab1,RUN and SH3 domain-containing protein 2
3	C (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	D (B)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
5	E, F (B, A)	water	water		18.0	231	Chemie (HOH)

Sequence modifications

B: 1 - 180 (UniProt: Q15286)

PDB	External Database	Details
Gly -5	-	expression tag
Pro -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
Glu -1	-	expression tag
Phe 0	-	expression tag
Leu 67	Gln 67	engineered mutation

A: 983 - 1181 (UniProt: Q8N2Y8)

PDB	External Database	Details
Gly 977	-	expression tag
Pro 978	-	expression tag
Gly 979	-	expression tag
Ser 980	-	expression tag
Glu 981	-	expression tag
Phe 982	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	43855.3
Non-Polymers*	Number of molecules	2
	Total formula weight	547.5
All*	Total formula weight	44402.8

*Water molecules are not included.