6IBR

Crystal structure of human alpha-galactosidase A in complex with alpha-galactose configured cyclophellitol epoxide LWA481

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha-galactosidase A	polymer	398	45394.5	2	UniProt (P06280) Pfam (PF16499) Pfam (PF17450)	Homo sapiens (Human)	Alpha-D-galactosidase A,Alpha-D-galactoside galactohydrolase,Melibiase
2	C, D (C, D)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
3	E, G (E, G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	F (F)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
5	H, I, J, K, X... (A, B)	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
6	AA, BA, CA, L, M... (B, A)	1,2-ETHANEDIOL	non-polymer		62.1	9	Chemie (EDO)
7	DA, R, S, T (B, A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	4	Chemie (PEG)
8	EA, FA, GA, HA, IA... (B, A)	ACETATE ION	non-polymer		59.0	6	Chemie (ACT)
9	JA, V (B, A)	(2~{R},3~{S},4~{S},5~{R},6~{S})-5-(hydroxymethyl)-7-oxabicyclo[4.1.0]heptane-2,3,4-triol	non-polymer		176.2	2	Chemie (HBE)
10	W (B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
11	KA, LA (A, B)	water	water		18.0	233	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	90789.1
Branched	Number of molecules	5
	Total formula weight	2770.6
Non-Polymers*	Number of molecules	29
	Total formula weight	2583.3
All*	Total formula weight	96143.0

*Water molecules are not included.