6I8T
THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH AN ISOINDOLINONE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Poly [ADP-ribose] polymerase 1 | polymer | 363 | 40627.6 | 1 | UniProt (P26446) Pfam (PF02877) Pfam (PF00644) In PDB | Gallus gallus (Chicken) | PARP-1,ADP-ribosyltransferase diphtheria toxin-like 1,ARTD1,NAD(+) ADP-ribosyltransferase 1,ADPRT 1,Poly[ADP-ribose] synthase 1 |
| 2 | A | (1~{R})-2-(1-cyclohexylpiperidin-4-yl)-1-methyl-3-oxidanylidene-1~{H}-isoindole-4-carboxamide | non-polymer | 355.5 | 1 | Chemie (H7Z) | |||
| 3 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A: 654 - 1014 (UniProt: P26446)
| PDB | External Database | Details |
|---|---|---|
| Gly 652 | - | expression tag |
| Pro 653 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40627.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 355.5 | |
| All* | Total formula weight | 40983.1 |
