6I7U

Alpha-1-antitrypsin (Ala250Met) in the native conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Alpha-1-antitrypsin	polymer	404	45671.9	1	UniProt (P01009) Pfam (PF00079)	Homo sapiens (Human)	Alpha-1 protease inhibitor,Alpha-1-antiproteinase,Serpin A1
2	B (A)	water	water		18.0	391	Chemie (HOH)

Sequence modifications

A: 2 - 394 (UniProt: P01009)

PDB	External Database	Details
Met -9	-	initiating methionine
Arg -8	-	expression tag
Gly -7	-	expression tag
Ser -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
Thr 1	-	expression tag
Met 250	Ala 274	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45671.9
All*	Total formula weight	45671.9

*Water molecules are not included.