6I6F

SEPIAPTERIN REDUCTASE IN COMPLEX WITH COMPOUND 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Sepiapterin reductase	polymer	276	29948.5	2	UniProt (P35270) Pfam (PF00106)	Homo sapiens (Human)	SPR
2	C, N (A, B)	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
3	D (A)	ethyl 4-azanyl-3-bromanyl-benzoate	non-polymer		244.1	1	Chemie (H4E)
4	E, F, G, H, I... (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
5	S, T (A, B)	water	water		18.0	206	Chemie (HOH)

Sequence modifications

A, B: 1 - 261 (UniProt: P35270)

PDB	External Database	Details
Met -14	-	initiating methionine
Gly -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Glu -6	-	expression tag
Asn -5	-	expression tag
Leu -4	-	expression tag
Tyr -3	-	expression tag
Phe -2	-	expression tag
Gln -1	-	expression tag
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	59896.9
Non-Polymers*	Number of molecules	16
	Total formula weight	2537.8
All*	Total formula weight	62434.7

*Water molecules are not included.