6I5H
Crystal structure of CLK1 in complex with furanopyrimidin VN412
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 1 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | B, C, E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 3 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | H (A) | 5-(1-methylpyrazol-4-yl)-3-(3-phenoxyphenyl)furo[3,2-b]pyridine | non-polymer | 367.4 | 1 | Chemie (H3N) | |||
| 5 | I (A) | water | water | 18.0 | 271 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
| Met 147 | - | expression tag |
| Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39581.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 769.8 | |
| All* | Total formula weight | 40351.3 |
