6I4X
Crystal structure of SOCS2:Elongin C:Elongin B in complex with erythropoietin receptor peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Elongin-B | polymer | 104 | 11852.4 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (Human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 2 | C | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (Human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 3 | A | Suppressor of cytokine signaling 2 | polymer | 169 | 19204.0 | 1 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) In PDB | Homo sapiens (Human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
| 4 | D | Erythropoietin receptor | polymer | 11 | 1322.3 | 1 | Homo sapiens | ||
| 5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 6 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
C: 17 - 112 (UniProt: Q15369)
A: 30 - 198 (UniProt: O14508)
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 31 | Pro 31 | conflict |
| Ala 115 | Lys 115 | conflict |
| Ala 117 | Lys 117 | conflict |
| Ala 118 | Gln 118 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43353.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 106.1 | |
| All* | Total formula weight | 43459.4 |
