6I3I

Crystal structure of reactive center loop (RCL) cleaved angiotensinogen

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Angiotensinogen	polymer	458	50647.7	1	UniProt (P01019) Pfam (PF00079)	Homo sapiens (Human)	Serpin A8
2	B (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
3	C (A)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A: 1 - 452 (UniProt: P01019)

PDB	External Database	Details
Gln 137	Asn 170	engineered mutation
Ser 232	Cys 265	engineered mutation
Gln 271	Asn 304	engineered mutation
Gln 295	Asn 328	engineered mutation
Ser 308	Cys 341	engineered mutation
His 453	-	expression tag
His 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	50647.7
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	50868.9

*Water molecules are not included.