6I2P
Crystal structure of the Mycobacterium tuberculosis PknB kinase domain (L33E mutant) in complex with its substrate GarA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase PknB | polymer | 280 | 30520.1 | 2 | UniProt (P9WI81) Pfam (PF00069) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | C, D (D, E) | Glycogen accumulation regulator GarA | polymer | 163 | 17322.9 | 2 | UniProt (P9WJA9) Pfam (PF00498) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 3 | E (C) | UNK-UNK-UNK-UNK-UNK | polymer | 5 | 443.5 | 1 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | ||
| 4 | F, I (A, B) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 2 | Chemie (ACP) | |||
| 5 | G, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | H, K, L (A, D) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 7 | M, N, O, P (A, B, D, E) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 279 (UniProt: P9WI81)
D, E: 1 - 162 (UniProt: P9WJA9)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Glu 33 | Leu 33 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 96129.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1347.2 | |
| All* | Total formula weight | 97476.7 |
